Statins - Beta Endorphins

Since the discovery in 1975 of internally produced opiates, popularly described as Beta endorphins and finally labeled as neuropeptides, legions of scientists have explored the nature and role of these ubiquitous substances.

Neuropeptides are biochemicals that regulate almost all life processes on a cellular level, thereby linking all body systems. Although produced primarily in the brain, every tissue in the body produces and exchanges neuropeptides,

They do not simply convey thought, sensation or emotion; these peptide clusters are the thought, sensation or emotion in a process we are only just beginning to understand. Statin drugs, while blocking cholesterol synthesis, collaterally block dolichol synthesis and function as well. Without dolichols the intricate process of neuropeptide formation and transport can not occur.

The process of neuropeptide biosynthesis begins in the cell nucleus where, somewhat like a conductor of a fine symphony, dolichols orchestrate the entire process. There is no disputing either statin's inhibition of dolichol synthesis or dolichols vital role in neuropeptide formation.

Since neuropeptides are involved intimately in so many areas of physiology, I can only advise caution and suggest that even the most obscure of patient symptoms may be associated with statin drug use.

Duane Graveline MD MPH
Former USAF Flight Surgeon
Former NASA Astronaut
Retired Family Doctor

Books From Amazon

The Dark Side of Statins
The Statin Damage Crisis
Cholesterol is Not the Culprit
Statin Drugs Side Effects
Lipitor, Thief of Memory

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