Gene responsible for statin-induced muscle pain

[cjbrooksjc]

It seems a good time to re-introduce a piece of info which seems to have subsided into this morass of forum data: the gene interaction responsible for muscle pain and injury during statin therapy. Also remember: if you are hypothyroid (lo thyroid), you are at greater risk of serious statin side effects.

http://www.physorg.com/news115381783.html

Best,

Brooks

[David Staup]

Brooks,

the expression of the Atrogin-1 gene is triggered when there are problems with energy production in the mitochondria. here are a few studies pointing out the connection between Atrogin1 and mitochondria:

"http://diabetes.diabetesjournals.org/content/early/2010/05/26/db10-0207.abstract

here is the conclusion:
berberine impairs muscle metabolism by two novel mechanisms. It impairs mitochonidrial function stimulating the expression of atrogin-1 without affecting phosphorylation of forkhead transcription factors. The increase in atrogin-1 not only stimulated protein degradation but also suppressed protein synthesis, causing muscle atrophy


and this one that shows how just fasting can cause the mitochondria to express atrogin1 gene:

"http://www.pnas.org/content/98/25/14440.abstract?related-urls=yes&legid=pnas;98/25/14440&cited-by=yes&legid=pnas;98/25/14440

providing everything you can for the functioning of the mito and limiting your energy usage are the keys to living with statin damage...it's all about the atp...never let it be depleted and you will not relapse

[damaged]

Brooks:
“info which seems to have subsided into this morass of forum dataâ€Â

[David Staup]

Mike,

I found some hints in the following booklet:

"http://drmyhill.co.uk/drmyhill/images/7/76/Cfs_book_27.pdf

it's long but well worth the effort as there is understanding and suggestions throughout.

don't let the CFS title throw you off as CFS is a mito disorder and in my case at least is a perfect fit ...if you throw in a few more symptoms

David

[damaged]

David:
'don't let the CFS title throw you off as CFS is a mito disorder and in my case at least is a perfect fit ...if you throw in a few more symptomsâ€Â

[David Staup]

mike,

this is the best answer to your question "Is CFS universally recognized as a legitimate ailment?"

" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680051/

the introduction explains, quite clearly, the current state of CFS understanding...this article is what led me to Dr. Myhill and her booklet...

I'm having the test done, probably at the end of this month just to see what I need to fine tune my supplimentation...I've already found my own way to most of the suggestions in the booklet. hopefully I can squeeze some more ability out.... the top thing on her list is to pace yourself, to learn what you can do and never to do more than 80% of that on any day. as we both know that is the problem !!!!! if you take nothing more from the booklet I believe that is the KEY point...

David

[lars999]

David,

I am greatly enjoying reading electronic version of Myhill's booklett, to which you posted link. Happily, I am already doing/done many of things she mentions -- and -- I now have some specific tests to consider including in my next roundel of tests.

Thanks!!
Lars