by cjbrooksjc » Wed Feb 28, 2007 9:10 pm
Catspjs: Here is an excerpt from a link I will provide below:
Pilot trial of high dosages of CoQ10 in patients with Parkinson's disease.
Exp Neurol. 2004 Aug;188(2):491-4.
The safety and tolerability of high dosages of coenzyme Q10 were studied in 17 patients with Parkinson's disease (PD) in an open label study. The subjects received an escalating dosage of coQ10 -- 1200, 1800, 2400, and 3000 mg/day with a stable dosage of vitamin E (alpha-tocopherol) 1200 IU/day. The plasma level of coQ10 was measured at each dosage. Thirteen of the subjects achieved the maximal dosage, and adverse events were typically considered to be unrelated to coQ10. The plasma level reached a plateau at the 2400 mg/day dosage and did not increase further at the 3000 mg/day dosage. Our data suggest that in future studies of CoQ10 in PD, a dosage of 2400 mg/day (with vitamin E/alpha-tocopherol 1200 IU/day) is an appropriate highest dosage to be studied.
This excerpt was found about five pages into this link. Sounds like you are concerned without reason. But, if you want to read more (and there is a LOT of it), go to:
[http://www.raysahelian.com/coq10.html]
Regards,
Brooks