New Patent App: Statin Side Effect Treatment

[cjbrooksjc]

This patent application is VERY interesting (but jargon-filled), and essentially touts three supplements as the remedy for Statin Side Effects:

CoQ10
Magnesium Orotate
Uridine

Treatment of Statin Side Effects - U.S. Patent application
**http://www.faqs.org/patents/app/20100144665

Brooks

[David Staup]

Brooks,

is there any study data on this or any reason to expect that some will actually benifit?

I ask this because I (and I believe you also ) have been taking all three for almost a year now and I for one have not seen ANY improvement.

I continue to relapse everytime I "over do" things reguardless of the suppliments.. the only gains I've made are small increments in how much it takes to "over do" and my experience is leading me to believe that that is most dependant on current condition at the time of the activity.


also when you look closely at the patent it actually is for adding these suppliments in coumpound WITH a statin either alone or in combination.
see lines (in the patent) 20, 27, 34, 38 .....an on and on covering all combinations

in other words this fellow is fishing, and to make it worse he probably has done no research but may have only been watching this very forum for his ideas!

fortunately the patent app will probably because at least one of the variations has already been patented by merick I believe, that being statin and coq-10

David

[David Staup]

in the last line I omitted the word FAIL after the word probably

David

[cjbrooksjc]

David: We all know that statin affected individuals react differently to different formulations of supplements, and correct supplement formulation is the most difficult thing to publish for such a diverse group as ours. Perhaps some of our group WILL find benefit in this triple supplement remedy. I certainly hope so.

The other reason I posted is that this formulation (as you noted) is not new. We (IOSV) heard of this from from European sources over a year ago, and I was wondering if any of our Spacedoc European constituency had any information on published findings there.

Best,

Brooks

[David Staup]

Brooks

this has all been mentioned here before, by you actually in august 09 and I recall no real reports of any improvements.

the first patent app for using uridine for statin effects was in 03 and I have found absolutely no reports of it's effectiveness

"http://www.wipo.int/pctdb/en/wo.jsp?wo=2003049730

Magnesium is actually also effective at lowering cholesterol, maybe more so than statins, and for many of us that may even be more harmful than good:

"http://www.jacn.org/cgi/reprint/23/5/501S.pdf

below is a link to a 6 year study (independant) of low dose statin users that includes the data on all cause mortality versus cholesterol levels and it's free. even the relative risk figures are disturbing and I have done the calculations for actual rates versus cholesterol levels which I'll post below the link to the study.

"http://dspace.lib.kanazawa-u.ac.jp/dspace/bitstream/2297/7526/1/ME-PR-MABUCHI-H-1087.pdf


The following data is from a study done in Japan in 2002 on 41,841 people from 35 to 70 years old, 2/3 of which were male. These patients were all on low dose statins . either 5 mg or 10 mg, the average reduction in TC was 18.4% , the average reduction in LDL-C was 26.8% and the average reduction in TG was 16.1%. This study is on the net for free (link below) and the data grouped by levels of TC, LDL-C, AND HDL-C and is included for all to see. I have done the calculations for the actual risks per 1,000 subjects (shown below) to make it clear as only the the relative risks are provided in the study linked below.




CARDIAC DEATHS


TC RATE/ 1000 STUDY POPULATION


<160 461 8.6

160-179 2065 2.4

180-199 7233 2

200-219 12494 .96

220-239 10671 1.4

240-259 5380 2.9

260-279 2110 2.8

>280 1387 6


Now the most disturbing, the all cause death rates versus total cholesterol and LDL


TC

<160 461 6.0

160-179 2065 3.7

180-199 7233 2.2

200-219 12494 1.7

220-239 10671 1.66

240-259 5380 1.46

260-279 2110 2.3

>280 1387 3.1



LDL-C

<80 839 3.5

80-99 3186 2.3

100-119 9376 2.2

120-139 12622 1.7

140-159 9089 1.7

160-179 3931 1.9

180-199 1403 1.8

>200 964 3.4


This information should cause everyone to re-examine thier beliefs on the link between cholesterol and mortality and longetivity!

Brooks we are all using ourselves as test subjects in this dangerous quest for relief and need to be aware that everything we try may have consequences that are unforseen

David

[David Staup]

I should have previewed !
I can't get the data in by pasting so I'll post it later by retyping but not now as my hands are in bad shape...

you might be able to figure it out

the first 6 numbers seperated by the hyphen are the cholesterol range and the last one or two numbers(two if there is a decimal point) are the rate/1000 and the remainder in the middle are the study population.

[David Staup]

Brooks I need to apologize here ...guess I'm in poorer shape than I thought ...
This exchange has led me to a link that includes a suppliment list for mito patients that includes all three suppliments and more plus explains a lot more ....this should be helpfull for all

check this out:
http://www.umdf.org/atf/cf/%7B28038C4C- ... 0FIRST.pdf

read past the inherited childhood part as it goes on to describe adult onset and possible causes then gets to treatment options, diagnosis, and testing sites
I can't understand how it is I never saw this before
David

[cjbrooksjc]

No problem, David. It is worth noting however that the supplements list in this link is found on pages 11 and 12 although there are no recommended dosages.
I have found supplementation to be the hardest subject to define in terms of a blanket application for all statin sufferers. I am still struggling with developing a "supplements" segment for the IOSV site as many individuals experience different REACTIONS TO and BENEFITS FROM various supplementation formulations. It is a puzzlement :?

Best,

Brooks

[David Staup]

note the following from the link
TREATMENT
- varies from patient to patient, depending on the exact
disorder and the severity of the disorder.

- as a general rule, patients with mild disorders tend to
respond to treatment better than those with severe disorders.

- in some circumstances, the treatment can be tailored
specifically to the patient, and that treatment is effective;
whereas in other circumstances, the treatment is “empiricâ€Â

[cjbrooksjc]

Yes, there are a number of these "lists" available and they all carry the same sort of categorical disclaimer. As for me and my supplement soup: today seems a pretty good day. I'm certain it has to do with a suppression of both statin-triggered autoimmune response and mitochondrial dysfunction, but I can't nail down any attributable specifics. It is truly frustrating.

Brooks