Craig, Astaxanthin is the cartenoid [similar to beta carotene] that gives salmon and shrimp their red coloring. In itself astaxanthin is a very powerful anti-oxidant, 500 times more powerful than vitamin E without the toxicity. And unlike many other anti-oxidants, which can generate their own free radicals, astaxanthin binds free radicals within the actual cell membrane. This greatly reduces the amount of oxidized-LDL within the blood stream. As we now know, oxidized lipoprotein is more strongly associated with heart disease and blood clotting, than the mere LDL particle alone.
Astaxanthin can help to maintain a healthy lipid profile much more safely and effectively than statins. Not only does it lower oxidized-LDL and triglycerides, but it also raises HDL and increases overall particle size. One astaxanthin study showed HDL cholesterol increased from an average 42 mg/dL to 58mg/dL, after just thirty days, or a substantial 27.5% increase.
Astaxanthin also greatly increases overall particle size. Scientists have found those with the highest HDL and largest lipoprotein particle size live longest.
Biological evidence for inheritance of exceptional longevity
Gil Atzmona, Marielisa Rinconb, Pegah Rabizadeha and Nir Barzilaia
Mechanisms of Ageing and Development
Volume 126, Issue 2, February 2005, Pages 341-345
"Moreover, we demonstrated that subjects with exceptional longevity and
their offspring have significantly larger high-density lipoprotein (HDL)
levels and particle sizes and low-density lipoprotein (LDL) levels that
reflect on their health and cognitive function performance."
Unique Lipoprotein Phenotype and Genotype Associated With Exceptional
Nir Barzilai, MD; Gil Atzmon, PhD
"Conclusions: Individuals with exceptional longevity and their offspring
have significantly larger HDL and LDL particle sizes. This phenotype is
associated with a lower prevalence of hypertension, cardiovascular disease,
the metabolic syndrome, and increased homozygosity for the I405V variant in
CETP. These findings suggest that lipoprotein particle sizes are heritable
and promote a healthy aging phenotype."
Also, I assumed you were referring to oral EDTA, being as you mentioned supplementation. When given orally EDTA is poorly absorbed and remains in the digestive tract. This can then block essential nutrients from being absorbed over a continuing period. Even more dangerous is the potential for an increase in the absorption/distribution or cytotoxicity of certain metals, including lead and cadium.
Final report on the safety assessment of EDTA
Int J Toxicol. 2002;21 Suppl 2:95-142.
Lanigan RS, Yamarik TA.
"The typical concentration of use of EDTA is less than 2%, with the other
salts in current use at even lower concentrations. The lowest dose reported
to cause a toxic effect in animals was 750 mg/kg/day. These chelating agents
are cytotoxic and weakly genotoxic, but not carcinogenic. Oral exposures to
EDTA produced adverse reproductive and developmental effects in animals."
EDTA intreveniously is a tiny bit better in many regards, yet also expensive and probably unnecessary given the host of other options. Although, there are also several risks concerning EDTA infusions as well, including: abnormally low blood pressure or hypotension, low blood sugar, major organ failure and damage, seizures etc.
There's a lot of misinformation about chelation out there, both good and bad. So it definitely makes sense to become educated on the potential benefits and dangers. Overall, it's probably best to test for toxic metals before embarking on major chelation therapy.
Donating blood would certainly be an effective way to get heavy metals out of the blood.
I also believe in IP6 as an inexpensive and safe chelator, especially when administered once every two weeks. Compounded over time these stronger chelators can become anti-nutrients, and increase the potential for anemia.
Along with Brian, I strongly believe in vitamin K2 (especially MK-7 or menaquinone-7) and also nattokinase. I have witnessed first-hand the profound anti-arteriosclerotic effects of these supplements first hand over a short period of two months. These two supplements should be the first line of defense for anyone suffering from diseased or blocked hearts and arteries.
Astaxanthin, vitamin d3 in gelcap form, vitamin K2, nattokinase... right there you have almost a perfect line of defense against cancer, heart disease, and strokes.
I hope this answers your questions. Anyway, the holidays have given me extra time to flesh out talking points and better attribute my position, which is always important, but not always possible.
I also wish everyone here a very happy and joyous Holiday Season, free of pain and disease.