Take a look at this:
I wanted to share a recent experience with you that is along the lines
of the Benadryl.
Several years ago I had tried taking a little DHEA to see if it would
help with low energy. I had a blood test and was within normal range,
but wanted to see what would happen. I believe I was taking about 15-20
mg. It made me extremely jumpy and angry, just like you'd see with high
estrogen or testosterone levels, so I stopped right away.
In 2003 when I contracted neuroinvasive West Nile Virus I developed
extensive damage to nerve roots in my spine.. At first the nerve damage
affected my entire torso, but over several years it seemed to heal
somewhat it localized more and appears to be a lesion in my thoracic
spine with total nerve loss at the T-10 region. This was so specific
that it only affected one very small section of my intestines and caused
gastroparesis. I could not sleep lying down unless I had not eaten
since afternoon. If there was any food in my upper GI tract I would wake
up with excrutiating pain and vomiting. The main treatment is an
implanted vagus nerve stimulator which I declined. EMGs showed such
severe axonal damage it didn't even pick up any electrical impulse in
This past year I started having some menopausal symptoms like hot
flashes and decided to revisit the DHEA since I didn't want to use
hormone replacement therapy. I took about 5 mg a day and it did relieve
the symptoms. I realized how much it had helped when I ran out for a
couple of weeks. So last week I started taking it again and decided to
double the dose. I didn't realize until a few days later that I was
using the higher potency capsules, 50 mg instead of 25, so I was getting
about 10 mg per day. I got up early one morning to go for a walk and was
greatly surprised to find I could walk up a long hill without getting
winded. I walked 1 1/2 miles and hardly felt it. But what was most
surprising was that my back and abdominal pain from the nerve damage had
improved quite dramatically. I could even lie down for a short time and
not get the nausea and bloating.
First I looked to see if DHEA could replenish the myelin sheath which is
what was damaged in my spine. I found many references:
http://www.plosbiology.org/article/info ... io.1001051
Then I looked to see if DHEA could possibly improve Pulmonary Arterial
Hypertension which I had also developed from viral infection. That would
explain my higher level of exercise tolerance. I found that they were
conducting clinical trials because it had been so effective.
It's interesting that the nerve damage is related to over-expression of
apoptosis, but the pulmonary hypertension from under-expression in the
vessels - the proliferation is what causes PH. So the DHEA seemed to
have a modulating effect on both my conditions.
Again, I think when you go with a lower dose you let the body determine
how it's going to use the compound. When I tried taking DHEA many years
ago the dose was just too high for me since I had high levels of
estrogen and it was probably being shunted that direction. Now that I
have low estrogen levels my body seems to be using it in a more diffused
way. This is probably true for men and testosterone related to DHEA
intake. If you do a search on PubMed for DHEA and apoptosis there are a
lot of interesting studies. Since we have so much Parkinson's in my
family which is probably mito-related and DHEA has been used as a
treatment, it made me wonder if it might be exerting the same protective
effect as the Benadryl.
I doubt that I could ever find a neurologist who would follow this line
of reasoning. I have tried to see a doctor at the University of
Colorado's MDA clinic, but because I refused to see his partner who is a
total jerk, I'm now on their black list and they won't give me an
appointment. I have been very active in promoting the MDA for several
decades since they treat the muscle disease that runs in my family, but
to punish someone because we want a choice in doctors is ridiculous.
Anyway, thought that might make some interesting reading for you. It was
discussed a little on the forum and I seem to recall you mentioned
pregnenolone. I'm using the Swanson Vitamins DHEA 50 mg capsule and
taking small doses.
There are conflicting lines of evidence that dhea in small doses increases glutathione or decreases it.......?????