from the mito group forum:
Many of you have either posted or read posts about
that big question..Do you or a family member actually have Mito or is it
something else, or a combination.
Then there is the problem of getting an appointment for a biopsy, which has it's
own sub-set of problems,
like will it be a fresh sample or a frozen sample and on that issue alone, there
are differing opinions from different doctors.
Then there is the question of the lab and the dreaded report, inconclusive, or
"If it were fresh rather than frozen, maybe I could have known better". Or ,one
lab is better than the other, but your doctor's hospital has a contract with a
local lab, locking your sample away from the more respected lab that understands
We have read some of all the above situations and more, many times.
We and our doctors are all pretty comfortable with the simple labs that go out
to a local lab and most are hard to really mess up, except maybe what is your
coQ10 level, that one many labs don't get right.
But if your really big question is, do you or a family member actually have Mito
and you are looking for an answer which does not depend on how good the person
is at interpreting what the mitochondria should look like in the lab ( beside
the DNA /mtDNA sequencing done by machine) and the time delay, if they are a
Well, it turns out that there is another tool we don't hear much about but it is
related to one we do hear much about, the MRI.
Since at least the 80's, there have been studies done and they got better at it,
for detecting Mito.
When you are measuring for Mito, first you see what the resting state level is
for ATP and compare that to what the existing resting state is also for ADP.
When ATP is used, the available energy is taken off ATP by striping off one
molecule and the stripped off version, minus some energy, is now ADP. The 'T'
stands for 'Tri' and the 'D' stands for 'Di'.
So, if you know how much ATP and ADP are present while at rest, then you do a
little work and get a second reading, If the ATP is low and the ADP is high, you
know the mitochondria are not recycling your ADP into ATP
and more, you have actual numbers in percentage, what is normal, what you are
producing and where you stand in results compared to normal averages.
Just like most lab results. Hard data, real numbers, no opinion or no wrong
And you can read it compared to normal numbers.
Well, that technology is called
"phosphorus magnetic resonance spectroscopy" and if you google that term, with
the quotes, you will get a lot of results and some great reading, good papers,
done about people like yourself.
First, you can get the scan while keeping your muscle right where it is and
without getting a chunk of you cut away. Later, if the numbers come back to show
you are not making much ATP from all the surplus ADP like you should, then yes,
very likely it is a mito issue, so you can go further, get the biopsy and get
the DNA done so you know which complex.
But if your question is mainly do you have Mito, this method may be worth
I like the idea of knowing and having a number put on it, of what percentage ATP
before working to what percentage ATP after working, did I make? You should keep
up while working.
In this re-cycling ADP to ATP process, you should be making about your body
weight in ATP a day..Granted it's a closed loop system but that goes to show you
how much of the stuff is used to live and work.
Understanding how the machine works is easy if you look at it this way. Each
material has a different signature, like a bunch of bells of different size,
each has it's own sound.
As you strike each bell, it sounds out with a unique signature.
In the machine, fields are like the bell striker. Each shows up in it's own
place on a graph or chart.
So, it's all about numbers and is not subject to human error, it's a spectra
showing what is there and how much of each.
So, first a baseline reading, then some work, then another reading.
Some studies were on Mito patients from the same family and really conclusive,
with detailed numbers.
All without cutting.
Some were on heart patients, without cutting, to see how much ATP vs ADP was
present, because many did not show problems with EKG but had pains.
The machine can spot ATP to ADP ratios before / after workout so much earlier,
it can tell you about the issue before even having Mito symptoms. I would call
that quite a value.
Instead of having to wait before it looks like it's needed, you can know really
Most docs would not order a biopsy without strong suspicion.
Plus the machine can look where you want, not just where the chunk of muscle was
What if the biopsy was not the most effected area? What good are the results?
Most of these machines are at universities and like it's cousin, the MRI, they
use magnetic fields in the 1.5 Tesla to 3 Tesla range magnetic field strength.
Unlike other scan systems, there is not a radiation problem.
I'll take a magnetic resonance scan any day of the week compared to the other
http://www.ncbi.nlm.nih.gov/pmc/article ... 2-0048.pdf