Dr. Duane Graveline, MD, MPH
Over 250 Articles - Listed by Category
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Dr. Duane Graveline, MD and others have submitted over 250 articles on Cholesterol, Statin Drugs and their Side Effects.
Statin Drugs Articles
Statin Drugs Side Effects Articles
Statin Books by Dr Duane Graveline MD, MPH
My first book, Lipitor®, Thief of Memory, was written after my two bouts of transient global amnesia (TGA) associated with the use of Lipitor® in the years 1999 - 2000. Predictably at that time, I was focused on cognitive dysfunction and Lipitor®.
I soon realized the adverse reactions involved far more than impaired cognition, including personality change, myopathy, neuropathy and a chronic neuromuscular degeneration similar to ALS and all statins were contributing to these adverse reactions, not just Lipitor®.
It was in this climate that I wrote my second book, Statin Drugs Side Effects. This is when I learned what reductase inhibition really meant. The reductase step blocked by statins was at the very beginning of the mevalonate pathway.
This pathway to cholesterol synthesis is also shared by many extremely important biochemical substances, including coenzyme Q10, inhibition of which was the cause of many of these side effects.
One cannot reduce cholesterol by the use of statins without simultaneously blocking these other biochemicals sharing the mevalonate pathway. My third book, the Statin Damage Crisis, was written to help people understand this.
In attempting to explain why many statin drug side effects such as neuropathy and myopathy often tended to persist regardless of CoQ10 supplementation, I discovered something far more ominous was going on.
Excessive CoQ10 inhibition was resulting in buildup of free radicals resulting in increased mitochondrial DNA damage and mutation, primary factors in how we age. Statin drugs were thereby enhancing aging. Statin associated CoQ10 inhibition was leading directly to increased mitochondrial DNA damage and premature senility. My fourth book that covers this is titled The Dark Side of Statins.
Duane Graveline, MD, MPH